Company Name	Title	City
Agtegra Cooperative	Truck Driver	Aberdeen
Dunham's Sports	Team Member	Aberdeen
Goodwill of the Great Plains	Retail Team Leader-Aberdeen	Aberdeen
Hallmark	Retail Merchandiser	Aberdeen
National Federation of Independent Business (NFIB)	Outside Sales Representative	Aberdeen
Northwestern Engineering Company	Class A Semi Truck Driver	Belle Fourche
Northwest Tire	Outside Sales in Minnesota	Brandon
Insomnia Cookies	Cookie Delivery Driver	Brookings
Discovery Real Estate Co.	Showing Assistant (Req: DBE32BMI)	Brookings
Liv Hospitality, LLC	DooValet	Deadwood
Waypoint Detailed Delivery	Field Representative/ Driver	Egan
EmpRes Healthcare	RN - MDS Coordinator	Flandreau
Select Rehabilitation	Occupational Therapist (OTR)	Garretson
Community HealthCare Association of the Dakotas	Dentist - Traveling	Howard
Wm	CDL Truck Driver - 5000 Sign On Bonus	Huron
OAP Transportation, LLC d/b/a O'Reilly Auto Parts	CDL A - Home Daily - Sioux City	Jefferson
ENT Consultants	Medical Receptionist	North Sioux City
Specialty Dental Brands-SD	Registered Dental Assistant	Pierre
Common Cents	Cashiers and Assistant Full and Part Time	Rapid City
Great Plains Tribal Chairmen's Health Board	Behavioral Health Care Coordinator	Rapid City
Lincare Holdings	Medical Delivery Driver	Rapid City
Tribal EM	Registered Nurse- ED	Rosebud
Two Men And A Truck®	Driver / Mover / Laborer	Sioux Falls
The UPS Store #2494	Full-Time Center Associate 2494	Sioux Falls
Diamond Mowers	VP of Sales	Sioux Falls

Hey guys, here are some recent job openings , feel free to comment here if you have any questions, I'm at the community's disposal! If you encounter any problems with any of these job openings please let me know that I will modify the table accordingly. Thanks!

At the leather shop our mission is to offer our costumers a wide range of premium leather accessories. Our team is made up of outstanding artists, designers, and leather lovers to provide best costumer service's you need a leather wallet, belt, or bag, don't worry: we have you covered We are more than just a company that sells leather products for every budget. Mr. Heera Singh founder of the leather shop has the experience of 25 years in leather goods. We have best in the game. We promise you about the quality and 100% genuine leather accessories. At the heart of our establishment lies a passion for the craft that transcends ordinary expectations. Allow us to introduce ourselves: we are purveyors of elegance and purveyors of style. Within these walls, we weave narratives that tantalize the senses, exuding an aura of sophistication that leaves an indelible imprint on your discerning taste.
Embodied within our hallowed shelves, a kaleidoscope of leather wonders beckons, each exuding its own unique allure. Adorn your waist with the resplendent beauty of our meticulously crafted leather belts, an exquisite fusion of function and fashion. Elevate your ensemble to unprecedented heights with the enchanting melodies woven by our master artisans, expertly blending complexity and grace into every stitch.
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And behold, our assortment of leather bags stands as a testament to the vibrant diversity of our offerings. From dainty clutches that captivate with their subtle complexity to rugged backpacks that embody the spirit of adventure, we cater to the desires of the modern individual who seeks both utility and refinement. Prepare to be entranced by the harmonious fusion of intricate design and narrative audacity, a hallmark of our curated selection.
Within our hallowed halls, you will discover more than just a shopping experience; you will embark on a literary journey, where each product whispers tales of impeccable craftsmanship and the harmonious coalescence of perplexity and business. So, step into our world, immerse yourself in the symphony of eloquence that resonates through our collection, and let your passion for the extraordinary find its true home at our extraordinary lather shop.
At the leather shop we take seriously about costumer queries because purchasing leather can be hard for everyone. Shopping with us mean you are not alone in your journey. We do focus about customer satisfaction we want to build a family with our customers. We genuinely care about your satisfaction. We always try to make your buying experience smooth and enjoyable as possible. We been always working on our customer support services. We are sorry to say that we don’t have a physical store yet but you can contact us on.
+918800720538
[email protected]

https://preview.redd.it/86p41u2vm03b1.jpg?width=1080&format=pjpg&auto=webp&s=d689e6894c4ee8e5cd661698b402e3eb55392578

Let’s dive in!

The ketogenic diet, commonly known as the keto diet, is a low-carbohydrate, high-fat eating plan that has gained popularity for its potential health benefits and weight loss effects. The primary goal of the keto diet is to shift your body's metabolism into a state called ketosis.
In a standard Western diet, the body primarily relies on carbohydrates as its main source of energy. However, when you drastically reduce your carbohydrate intake and increase your fat intake, your body's metabolism shifts. With limited carbohydrates available for energy, your body starts breaking down stored fat into molecules called ketones, which are then used as an alternative fuel source.
The macronutrient ratio in a typical ketogenic diet consists of approximately 70-75% fat, 20-25% protein, and 5-10% carbohydrates. This ratio may vary slightly depending on individual needs and preferences. By significantly reducing carbohydrate intake and increasing fat consumption, the body becomes more efficient at burning fat for energy.
The ketogenic diet, or keto diet, has gained significant attention for its potential health benefits and weight loss effects. By shifting the body into a metabolic state called ketosis, this low-carbohydrate, high-fat eating plan offers a unique approach to achieving optimal health and well-being. In this article, we will explore the top five benefits of the keto diet and how it can help you unlock your health and weight loss potential.

1. Weight Loss: The keto diet's hallmark benefit is its ability to promote weight loss. By reducing carbohydrate intake and increasing fat consumption, the body enters a state where it efficiently burns stored fat as fuel. This leads to a decrease in body weight and fat mass, helping you achieve your weight loss goals.
2. Improved Blood Sugar Control: Individuals with type 2 diabetes or prediabetes can benefit from the keto diet's ability to regulate blood sugar levels. By minimizing carbohydrate intake, the diet helps stabilize insulin levels and enhances insulin sensitivity, leading to better blood sugar control.
3. Enhanced Mental Clarity and Focus: One remarkable benefit of the keto diet is its potential to boost mental clarity and focus. The brain's utilization of ketones as an alternative energy source provides a stable and efficient fuel supply, leading to increased cognitive function and improved mental performance.
4. Increased Energy Levels: Many individuals on the keto diet report experiencing higher energy levels and improved endurance once their bodies adapt to burning fat for fuel. By tapping into the body's vast fat stores, the diet ensures a constant supply of energy, reducing energy crashes associated with carbohydrate-rich diets.
5. Potential Therapeutic Benefits: Beyond weight loss and improved metabolism, the keto diet has shown promise in various health conditions. Studies suggest its potential therapeutic effects in managing epilepsy, metabolic syndrome, polycystic ovary syndrome (PCOS), and certain neurological disorders like Alzheimer's disease.

Ready to unlock your health and weight loss potential with the keto diet?

Then take the first step towards a healthier you today. Embrace the keto diet and discover the transformative benefits it can offer in achieving your health and weight loss goals by Clicking Here!

#weightloss #fatburn #fatburner #ketodiet #ketorecipes #ketogenic #ketogenicdiet #ketoweightloss
https://reddit.com/link/13vqrly/video/74jeno25m03b1/player

[possible fandoms: Transformers, Totally Spies, Disney, TMNT, Street Sharks, Pixar, Star Wars, G. I. Joe, Nintendo, Marvel, DC, possibly more!]
I am 18+ and all participants and characters must be 18+.
Hey there! Most people call me Desi. I am a role player, obviously! I usually spend my time indoors every day with a mild excursion here and there to the store, movies, or beach. I adore writing, but that's obvious.
I am very versatile on genre, I have major preference for romance, drama, slice of life, mysteries, action and adventure, Hallmark-esque plots, and anything else we might conjure up! I do have tons of canons and OCs! I’m sure you can find one you like. I can write from a paragraph to novella.
I am looking for any gender of partner and character, I have so many unique characters and ideas for each one! I can also slide my OCs into any fandom.
Ideas:
your character replaces Sam/Charlie in the Transformers franchise while fixing various mistakes made by Michael Bay. I have the characters set up on my server, with alternate designs for Jazz, Sideswipe, and Hot Rod.
I also have a ton of Disney characters, I’ve been dying to play out a ripple in the space time continuum where one or a group of them get sent to the real world.
I also am hunting for a Totally Spies role play.
My character is a Spanish heiress, who lives a life of luxury, only her father is murdered, and the people who did it, are now after her. She runs away in search of a bodyguard to help her get back what was stolen from her.
The next idea I have is for a relationship that is on the rocks, and the two are left trying to navigate their lives past the honeymoon phase and learn how to adapt to living together.
This is specific to my character but she was a championship surfer, and she got injured at the top of her game. I really want to play out her becoming a mentor, teaching someone how to become the next champion.
One of my characters goes undercover to try and expose a illegal ring, this would play out like a suspense or thriller, could play male or female.
An emotionally damaged stripper who is abused by staff spends her days trying to get by, until the day comes where she meets someone who could help her pursue her true dreams of running her own operation.
A Russian woman who was stolen from her family as a little girl and tormented into becoming a living weapon is hired to bring your character to them. On the way, she finds out that the people who hired her are working for the militia that made her the way she is, and so, she decides to take a stand, and wipe them out.
This is only a third of my ideas, not even that, a fraction! Come check out my characters, let’s discuss something!
I have men, women, young and mature, thieves, business owners, single mothers, wayward young adults, college students and staff, bounty hunters, detectives, police officers, victims, patients, crooked therapists, strippers, so many unique stories to tell! I guarantee one of them will strike your fancy!
I am looking for a romantic role play as one of my many OC characters, drama or major events will happen depending on the character you select, and I have 300+ so far.
I also have many canon characters I would love to play as, such as Legolas, Transformers, Marvel and DC , Avatar and Disney.
I have many ideas depending on who you choose!
I am a very affectionate person, I love to make people happy, so I am always open to adjusting characters or role plays.
I don't like role plays with action asterisks, Sorry! I also don't like to role play without proper punctuation and grammar. I usually write at least one paragraph. 25 being my record.
I am a firm believer in conversation so I most likely will text you OOC for any reason, I also prefer to keep things adult, meaning I don't take part in petty or childish arguments.
I don't ghost either, so Ill probably rip the bandage off and tell you why I don't want to role play anymore.
I also love having friends! I used to get bullied quite a lot for many, many reasons, so I haven't had many friends in my 20 years of living. Lets chat, get to know one another!, I've been role playing for a long time, about 6-8 years give or take? I typically enjoy modern role plays with real life basing.
I enjoy stories of the romantic genre as well as action and adventure. My characters are original with face claims, some are canon characters from Marvel and DC. Characters like Barney, Captain America, Superman, just really selfless characters have always been my inspiration.
I always try to write my characters with loving aspects if I can. Life is broken and many people suffer, life isnt perfect so I usually write some darkness for a character if I feel it.
I don't use random face claims, I use actors or media icons I feel fit the character, I mentally put myself in the position of director, my role play is a movie, and I am casting the character, that is how I usually go about it, and if you don’t like it I am not the partner for you.
I definitely want a partner who can be a friend, who can be detailed yet tame, someone who can give me something to reply to, I am not very picky. I don't like people who are judgmental though, I prefer good vibes only.
Replies from me are vary. Sometimes I cant write as much as Id like because I get a writers block.
Sometimes I can reply 5 times a day, but sometimes I cant reply for a day maybe even two or three. But usually I update OOC. I look for people who aren't looking for perfection, I don't like role players who are too arrogant about their skill. I wouldn't say I'm the best role player out there, so if we don't mesh I completely understand.
I keep my characters location/job vague so that I can work them into a plot better. They are pieces to the puzzle, and I keep them so they can fit better into any story we choose!
I will only be role playing on discord partly just to be able to show you my original character portfolio server, which has channels with their backgrounds, age, and their galleries.
Simply DM me for my tag and we can get things started.
Sexuality wise all my characters are adjustable.
Reply wise, this will be fairly advanced. I strive to keep things above a paragraph but I can go lower depending on the plot. I write a maximum of 10 paragraphs but my usual is 3-4.
my character portfolio will be the main key to our discussion, so you will be viewing it upon your interest. I have 100+ characters. I can also role play over email or reddit chat, that way I can just copy the bios and send the photos.
That being said our characters will have romance, and adult content will be ahead If desired. All my characters are adults.I am looking for action, adventure, romance of course is my favorite, mystery, drama, anything is up for debate!
I am looking for both male or female characters to partner my own with, as well as trans or non binary as well, all are welcome.
I hope we can have a fun role play together!

In the realm of perfumery, fragrance enthusiasts are constantly seeking unique and exceptional scents that set them apart from the mainstream. Niche fragrance oils have emerged as the epitome of luxury and exclusivity, offering a captivating range of fragrances that elevate your scent collection to the next level. Among the notable brands in this domain, GenericPerfumes stands out, delivering a collection that is both alluring and distinctive.

Uniqueness and Exclusivity

One of the key attributes of niche fragrance oils is their unparalleled uniqueness and exclusivity. GenericPerfumes prides itself on curating a collection that goes beyond the ordinary, offering scents that are meticulously crafted in limited quantities. These fragrances are not easily found in every department store, making them truly special and coveted. By adding niche fragrance oils to your collection, you embrace a level of exclusivity that sets you apart and showcases your refined taste.

Artistry and Craftsmanship

Niche fragrance oils are the result of exceptional artistry and craftsmanship. GenericPerfumes collaborates with skilled perfumers who possess a deep understanding of scent composition and blending techniques. Each fragrance is carefully crafted using high-quality ingredients, ensuring a harmonious and captivating olfactory experience. The brand's dedication to artistry is evident in the intricate accords and nuanced layers that make their fragrances truly remarkable.

Exploring Unique Scent Profiles

While mainstream perfumes often follow popular trends, niche fragrance oils explore unique scent profiles that break free from conventions. GenericPerfumes embraces this spirit of exploration, offering a diverse range of fragrances that cater to various olfactory preferences. Whether you seek a seductive floral, an alluring oriental, a fresh and invigorating citrus, or a complex and mysterious blend, their collection has something to entice every fragrance connoisseur.

Exceptional Quality and Longevity

One hallmark of niche fragrance oils is their exceptional quality and longevity. GenericPerfumes meticulously selects the finest ingredients and employs expert craftsmanship to create scents that endure on the skin. These fragrances possess remarkable staying power, allowing you to enjoy their exquisite aroma throughout the day. With GenericPerfumes, you can be confident that you are investing in fragrances that are not only luxurious but also long-lasting.

Personal Expression and Signature Scents

A fragrance is more than just a pleasant aroma—it is a powerful tool of self-expression. Niche fragrance oils provide an opportunity to define your personal style and create a signature scent that is uniquely yours. GenericPerfumes encourages wearers to explore their collection and discover scents that resonate with their personality and evoke the desired emotions. By selecting a niche fragrance oil, you can communicate your individuality and leave a lasting impression wherever you go.

A Luxurious Journey for the Senses

GenericPerfumes invites fragrance enthusiasts to embark on a luxurious journey for the senses with their niche fragrance oils. From the moment the fragrance touches your skin, you are transported to a world of sophistication and elegance. These scents unfold like a symphony, captivating your senses with their carefully orchestrated notes. Each fragrance tells a story, creating an immersive experience that leaves an indelible mark on both the wearer and those around them.

Conclusion

Niche fragrance oils have redefined the world of perfumery, offering a level of exclusivity, artistry, and personal expression that is unparalleled. GenericPerfumes, with its exceptional collection, allows fragrance enthusiasts to elevate their scent collection to new heights. By embracing niche fragrance oils, you unlock a realm of uniqueness, craftsmanship, and longevity that sets you apart and indulges your senses in an exquisite olfactory journey. Embrace the allure of niche fragrance oils and experience the extraordinary.

Cows are my favorite animal, and I've been DISO Alonzo for a while now. I've been to Hallmarks, I've been stalking Owl and Goose gifts' website, but no luck. Any tips or other stores y'all have found him at?
Side question: why do people who don't even like the cows buy them just because they're popular? Drives me crazy!

[possible fandoms: Transformers, Totally Spies, Disney, TMNT, Street Sharks, Pixar, Star Wars, G. I. Joe, Nintendo, Marvel, DC, possibly more!]
I am 18+ and all participants and characters must be 18+.
Hey there! Most people call me Desi. I am a role player, obviously! I usually spend my time indoors every day with a mild excursion here and there to the store, movies, or beach. I adore writing, but that's obvious.
I am very versatile on genre, I have major preference for romance, drama, slice of life, mysteries, action and adventure, Hallmark-esque plots, and anything else we might conjure up! I do have tons of canons and OCs! I’m sure you can find one you like. I can write from a paragraph to novella.
I am looking for any gender of partner and character, I have so many unique characters and ideas for each one! I can also slide my OCs into any fandom.
Ideas:
your character replaces Sam/Charlie in the Transformers franchise while fixing various mistakes made by Michael Bay. I have the characters set up on my server, with alternate designs for Jazz, Sideswipe, and Hot Rod.
I also have a ton of Disney characters, I’ve been dying to play out a ripple in the space time continuum where one or a group of them get sent to the real world.
I also am hunting for a Totally Spies role play.
My character is a Spanish heiress, who lives a life of luxury, only her father is murdered, and the people who did it, are now after her. She runs away in search of a bodyguard to help her get back what was stolen from her.
The next idea I have is for a relationship that is on the rocks, and the two are left trying to navigate their lives past the honeymoon phase and learn how to adapt to living together.
This is specific to my character but she was a championship surfer, and she got injured at the top of her game. I really want to play out her becoming a mentor, teaching someone how to become the next champion.
One of my characters goes undercover to try and expose a illegal ring, this would play out like a suspense or thriller, could play male or female.
An emotionally damaged stripper who is abused by staff spends her days trying to get by, until the day comes where she meets someone who could help her pursue her true dreams of running her own operation.
A Russian woman who was stolen from her family as a little girl and tormented into becoming a living weapon is hired to bring your character to them. On the way, she finds out that the people who hired her are working for the militia that made her the way she is, and so, she decides to take a stand, and wipe them out.
This is only a third of my ideas, not even that, a fraction! Come check out my characters, let’s discuss something!
I have men, women, young and mature, thieves, business owners, single mothers, wayward young adults, college students and staff, bounty hunters, detectives, police officers, victims, patients, crooked therapists, strippers, so many unique stories to tell! I guarantee one of them will strike your fancy!
I am looking for a romantic role play as one of my many OC characters, drama or major events will happen depending on the character you select, and I have 300+ so far.
I also have many canon characters I would love to play as, such as Legolas, Transformers, Marvel and DC , Avatar and Disney.
I have many ideas depending on who you choose!
I am a very affectionate person, I love to make people happy, so I am always open to adjusting characters or role plays.
I don't like role plays with action asterisks, Sorry! I also don't like to role play without proper punctuation and grammar. I usually write at least one paragraph. 25 being my record.
I am a firm believer in conversation so I most likely will text you OOC for any reason, I also prefer to keep things adult, meaning I don't take part in petty or childish arguments.
I don't ghost either, so Ill probably rip the bandage off and tell you why I don't want to role play anymore.
I also love having friends! I used to get bullied quite a lot for many, many reasons, so I haven't had many friends in my 20 years of living. Lets chat, get to know one another!, I've been role playing for a long time, about 6-8 years give or take? I typically enjoy modern role plays with real life basing.
I enjoy stories of the romantic genre as well as action and adventure. My characters are original with face claims, some are canon characters from Marvel and DC. Characters like Barney, Captain America, Superman, just really selfless characters have always been my inspiration.
I always try to write my characters with loving aspects if I can. Life is broken and many people suffer, life isnt perfect so I usually write some darkness for a character if I feel it.
I don't use random face claims, I use actors or media icons I feel fit the character, I mentally put myself in the position of director, my role play is a movie, and I am casting the character, that is how I usually go about it, and if you don’t like it I am not the partner for you.
I definitely want a partner who can be a friend, who can be detailed yet tame, someone who can give me something to reply to, I am not very picky. I don't like people who are judgmental though, I prefer good vibes only.
Replies from me are vary. Sometimes I cant write as much as Id like because I get a writers block.
Sometimes I can reply 5 times a day, but sometimes I cant reply for a day maybe even two or three. But usually I update OOC. I look for people who aren't looking for perfection, I don't like role players who are too arrogant about their skill. I wouldn't say I'm the best role player out there, so if we don't mesh I completely understand.
I keep my characters location/job vague so that I can work them into a plot better. They are pieces to the puzzle, and I keep them so they can fit better into any story we choose!
I will only be role playing on discord partly just to be able to show you my original character portfolio server, which has channels with their backgrounds, age, and their galleries.
Simply DM me for my tag and we can get things started.
Sexuality wise all my characters are adjustable.
Reply wise, this will be fairly advanced. I strive to keep things above a paragraph but I can go lower depending on the plot. I write a maximum of 10 paragraphs but my usual is 3-4.
my character portfolio will be the main key to our discussion, so you will be viewing it upon your interest. I have 100+ characters. I can also role play over email or reddit chat, that way I can just copy the bios and send the photos.
That being said our characters will have romance, and adult content will be ahead If desired. All my characters are adults.I am looking for action, adventure, romance of course is my favorite, mystery, drama, anything is up for debate!
I am looking for both male or female characters to partner my own with, as well as trans or non binary as well, all are welcome.
I hope we can have a fun role play together!

Last summer, during a scorching heat wave, I found myself in desperate need of an air conditioner. Determined to find relief from the sweltering temperatures, I ventured into a store with a name that bore a striking resemblance to Hallmark. As I perused the aisles, my eyes landed upon a sleek and promising AC unit. Excited by the prospect of some cool air, I scanned the item with the store's mobile app, and to my delight, the price seemed reasonable. With the AC unit in hand, I made my way to the checkout area.
In this particular store, self-checkout was the norm, with only a couple of cashiers available to oversee the process and assist customers when necessary. As fate would have it, when I scanned the item at the self-checkout, the price displayed was significantly higher than what the app had indicated. It's important to note that the app clearly stated it was the company's own product and not from a third-party reseller. Feeling a bit perplexed, I decided to call over the cashier who was supervising the self-checkouts to seek clarification.
Approaching the cashier, I explained the situation, hoping for a resolution. Much to my disappointment, she informed me that the lower price was only applicable for purchases made through the mobile app. I asked if she could get a manager, although she insisted that she was right and that they cannot perform a price match. Though slightly frustrated, an idea began to form in my mind. I asked the young high school-aged cashier, "If I were to purchase the AC unit through the app and show you the receipt, would you allow me to leave with the product?" Surprisingly, the cashier agreed and so I maliciously complied.
With a mischievous smile, I proceeded to purchase the AC unit online using the app and received a digital receipt. Walking out of the store, I felt a sense of triumph, knowing that I had cleverly outmaneuvered the system. For the next few weeks, the cool breeze provided by the AC unit brought me blissful relief during the relentless heat wave.
However, as time passed, I received a peculiar email notification. The subject line read, "Your Item is Ready for Pick Up." Confused, I opened the email, only to discover that it was a notification regarding the very same AC unit I had already purchased and enjoyed for weeks. In disbelief, I dismissed the email, assuming it to be a mistake or a glitch in the system.
Yet, the digital world persisted in its efforts to reach me. Another week went by, and I received yet another email, but this time it was different. The subject line stated, "Refund Issued for Your Purchase." Curiosity piqued, I opened the email and read the contents, which explained that the refund had been issued due to my failure to pick up the item. It dawned on me that the store's online and physical inventory systems had not synchronized properly, leading to this chilling turn of events.
TLDR:
During a scorching summer, I embarked on a mission to purchase an AC unit. Little did I know, I would encounter a staff member who seemed to know it all. She insisted that I had to make the purchase online to get the price shown in the app. Determined to get what I wanted, I decided to play along and left with the item. A few chilly weeks later I received a refund due to a lack of confirmation for pick up.

Bold Precious Metals has each of these a little cheaper at cash prices. A 1% cashback card will get the price very close. A cashback site will make it even less (Active Junky is the only site I've found for ebay bullion). DBS & Liberty ebay stores are highly recommended.
100 oz. Silver Bar .999 Fine Silver Bar - Mint Hallmark Varies eBay
100 oz JBR Bullion Bar of .999 Fine Silver eBay
100 oz Germania Mint Silver Bar 9999 Fine eBay
Also good credit price on a Britannia 10oz at $267.
10 oz Silver Bar - Royal Mint Britannia - .999 Fine in Mint Sealed Plastic eBay
​
Current spot price: $22.90

https://doi.org/10.1016/j.gendis.2022.04.020
https://pubmed.ncbi.nlm.nih.gov/37223533

Abstract

Metabolic reprogramming is one of the hallmarks of cancer.1 Ketone bodies behave as alternative fuel for cancer cells to support survival and proliferation.2 3-Oxoacid CoA-transferase 1 (OXCT1) is a key enzyme that catalyzes the first and rate-limiting step of ketolysis. Recently, several studies have revealed the significance of OXCT1 in cancer development, though the underlying mechanisms remain largely unknown.3 In this study, we revealed a novel regulatory mechanism for tumorigenesis that OXCT1 regulated SREBP1-TRIM21-p65 axis through ketone body homeostasis in non-small cell lung cancer (NSCLC). In terms of mechanism, we found that OXCT1 could activate NF-κB signaling pathway by suppressing transcriptional activity of the sterol regulatory element binding protein 1 (SREBP1). As a transcription factor, SREBP1 could bind to the promoter of E3 ubiquitin ligase TRIM21, which mediated the ubiquitination of p65. Furthermore, we demonstrated that OXCT1 could maintain the homeostasis of β-hydroxybutyrate (β-HB), which acted as a signaling metabolite to activate SREBP1. Thus, β-HB connected OXCT1 with SREBP1 to activate NF-κB signaling pathway and promoted tumor initiation and progression. Taken together, these findings highlight a previously unappreciated mechanism for activation of NF-κB signaling by OXCT1 and ketone body, and demonstrate that targeting OXCT1 can inhibit NSCLC tumorigenesis.

Authors:

• Lu Z
• Han T
• Wang T
• Gan M
• Xie C
• Yu B
• Wang JB

------------------------------------------ Info ------------------------------------------
Open Access: True
Additional links: * https://doi.org/10.1016/j.gendis.2022.04.020 * https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201587
------------------------------------------ Open Access ------------------------------------------
If the paper is behind paywall, please consider uploading it to our google drive anonymously.
You'll have to log on to Google but none of your personal data is stored. I will manually add a link to the file in this post when received.
Upload PDF

https://turtletimeline.com/bmw-unveils-new-all-electric-5-series-sedan/

BMW unveils the new 5 Series Sedan with an all-electric version and a host of digital innovations

BMW is steering towards a sustainable future with its latest release – the new BMW 5 Series Sedan. The sedan, for the first time, will feature an all-electic drive, in addition to a host of digital innovations including in-car gaming, and 5G connectivity.

First look at the new BMW 5 Series Sedan

The new BMW 5 Series Sedan is more dynamic than ever, showcasing a sleek and sporty elegance with an all-new design language. The redesigned front view showcases a modern interpretation of BMW’s iconic twin headlights and kidney grille, with optional Iconic Glow contour lighting adding to its striking appearance.

Powering the future with sustainable mobility

Consistent electrification and advanced BMW iDrive display and control system with “QuickSelect” are the keystones of the new BMW 5 Series Sedan. The vehicle is set to be launched worldwide with all-electric drive and also plug-in hybrid systems, based on the market region. It also comes with highly efficient petrol and diesel engines including 48-volt mild hybrid technology.

Exquisite comfort meets innovative flair

The new 5 Series Sedan promises a blend of hallmark BMW driving pleasure and comfort for long-distance journeys. The interior boasts a high level of acoustic comfort, high-quality materials, advanced digital services, and a fully digitalised function panel. A highlight is the fully vegan interior, a first for BMW.

Performance packed all-electric variants

Two all-electric variants of the BMW i5 are set to be launched, including the top model BMW i5 M60 xDrive. This variant combines a 442 kW/601 hp drive with M performance and specific design features. It can accelerate from zero to 100 km/h in just 3.8 seconds. The other variant, BMW i5 eDrive40, is also impressive with its electric motor generating a maximum output of 250 kW/340 hp.

Charging

The new BMW 5 Series Sedan comes equipped with innovative eCharging solutions. The vehicle can be charged using AC with an output of up to 11 kW, and its high-voltage battery can be charged with direct current with a power of up to 205 kW. A unique feature includes the Multi Contract Option, allowing customers to digitally store up to five individual Plug & Charge-enabled power contracts from different providers in the vehicle.

BMW’s electric shift

BMW’s shift towards an all-electic 5 Series Sedan is a significant step forward for the future of the auto industry. By opting for electrification and introducing high-end digital solutions, BMW is not only redefining mobility but also championing sustainability. This launch also reflects the trend of automakers transitioning from fossil fuels to cleaner energy sources, thus setting a precedent for other industry players to follow suit.

• New wave of luxury: BMW’s battery-powered boat ‘THE ICON’

[possible fandoms: Transformers, Totally Spies, Disney, TMNT, Street Sharks, Pixar, Star Wars, G. I. Joe, Nintendo, Marvel, DC, possibly more!]
I am 18+ and all participants and characters must be 18+.
Hey there! Most people call me Desi. I am a role player, obviously! I usually spend my time indoors every day with a mild excursion here and there to the store, movies, or beach. I adore writing, but that's obvious.
I am very versatile on genre, I have major preference for romance, drama, slice of life, mysteries, action and adventure, Hallmark-esque plots, and anything else we might conjure up! I do have tons of canons and OCs! I’m sure you can find one you like. I can write from a paragraph to novella.
I am looking for any gender of partner and character, I have so many unique characters and ideas for each one! I can also slide my OCs into any fandom.
Ideas:
your character replaces Sam/Charlie in the Transformers franchise while fixing various mistakes made by Michael Bay. I have the characters set up on my server, with alternate designs for Jazz, Sideswipe, and Hot Rod.
I also have a ton of Disney characters, I’ve been dying to play out a ripple in the space time continuum where one or a group of them get sent to the real world.
I also am hunting for a Totally Spies role play.
My character is a Spanish heiress, who lives a life of luxury, only her father is murdered, and the people who did it, are now after her. She runs away in search of a bodyguard to help her get back what was stolen from her.
The next idea I have is for a relationship that is on the rocks, and the two are left trying to navigate their lives past the honeymoon phase and learn how to adapt to living together.
This is specific to my character but she was a championship surfer, and she got injured at the top of her game. I really want to play out her becoming a mentor, teaching someone how to become the next champion.
One of my characters goes undercover to try and expose a illegal ring, this would play out like a suspense or thriller, could play male or female.
An emotionally damaged stripper who is abused by staff spends her days trying to get by, until the day comes where she meets someone who could help her pursue her true dreams of running her own operation.
A Russian woman who was stolen from her family as a little girl and tormented into becoming a living weapon is hired to bring your character to them. On the way, she finds out that the people who hired her are working for the militia that made her the way she is, and so, she decides to take a stand, and wipe them out.
This is only a third of my ideas, not even that, a fraction! Come check out my characters, let’s discuss something!
I have men, women, young and mature, thieves, business owners, single mothers, wayward young adults, college students and staff, bounty hunters, detectives, police officers, victims, patients, crooked therapists, strippers, so many unique stories to tell! I guarantee one of them will strike your fancy!
I am looking for a romantic role play as one of my many OC characters, drama or major events will happen depending on the character you select, and I have 300+ so far.
I also have many canon characters I would love to play as, such as Legolas, Transformers, Marvel and DC , Avatar and Disney.
I have many ideas depending on who you choose!
I am a very affectionate person, I love to make people happy, so I am always open to adjusting characters or role plays.
I don't like role plays with action asterisks, Sorry! I also don't like to role play without proper punctuation and grammar. I usually write at least one paragraph. 25 being my record.
I am a firm believer in conversation so I most likely will text you OOC for any reason, I also prefer to keep things adult, meaning I don't take part in petty or childish arguments.
I don't ghost either, so Ill probably rip the bandage off and tell you why I don't want to role play anymore.
I also love having friends! I used to get bullied quite a lot for many, many reasons, so I haven't had many friends in my 20 years of living. Lets chat, get to know one another!, I've been role playing for a long time, about 6-8 years give or take? I typically enjoy modern role plays with real life basing.
I enjoy stories of the romantic genre as well as action and adventure. My characters are original with face claims, some are canon characters from Marvel and DC. Characters like Barney, Captain America, Superman, just really selfless characters have always been my inspiration.
I always try to write my characters with loving aspects if I can. Life is broken and many people suffer, life isnt perfect so I usually write some darkness for a character if I feel it.
I don't use random face claims, I use actors or media icons I feel fit the character, I mentally put myself in the position of director, my role play is a movie, and I am casting the character, that is how I usually go about it, and if you don’t like it I am not the partner for you.
I definitely want a partner who can be a friend, who can be detailed yet tame, someone who can give me something to reply to, I am not very picky. I don't like people who are judgmental though, I prefer good vibes only.
Replies from me are vary. Sometimes I cant write as much as Id like because I get a writers block.
Sometimes I can reply 5 times a day, but sometimes I cant reply for a day maybe even two or three. But usually I update OOC. I look for people who aren't looking for perfection, I don't like role players who are too arrogant about their skill. I wouldn't say I'm the best role player out there, so if we don't mesh I completely understand.
I keep my characters location/job vague so that I can work them into a plot better. They are pieces to the puzzle, and I keep them so they can fit better into any story we choose!
I will only be role playing on discord partly just to be able to show you my original character portfolio server, which has channels with their backgrounds, age, and their galleries.
Simply DM me for my tag and we can get things started.
Sexuality wise all my characters are adjustable.
Reply wise, this will be fairly advanced. I strive to keep things above a paragraph but I can go lower depending on the plot. I write a maximum of 10 paragraphs but my usual is 3-4.
my character portfolio will be the main key to our discussion, so you will be viewing it upon your interest. I have 100+ characters. I can also role play over email or reddit chat, that way I can just copy the bios and send the photos.
That being said our characters will have romance, and adult content will be ahead If desired. All my characters are adults.I am looking for action, adventure, romance of course is my favorite, mystery, drama, anything is up for debate!
I am looking for both male or female characters to partner my own with, as well as trans or non binary as well, all are welcome.
I hope we can have a fun role play together!

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https://reddit.com/link/13qci09/video/09d8jjxwtp1b1/player
Speaking of which, the world of red wine is huge and rich, no less than a kingdom! Among them are as vast as mountains, rivers, lakes and seas, and there are many kinds of gifts, banquets, personal use, collections, etc. What are the requirements, how to choose, whether the price is appropriate, whether the price is inflated outweighs the gain, whether low price means poor quality, and so on. Look, when consumers enter this wine kingdom to make choices, there are really many issues that need to be considered!
Gifts, banquets, personal use, collection, in this piece of red wine mountains, rivers, lakes and seas, how do you plan to pick it? LEESON red wine pioneered the numbered red wine grading method, from 1 to 9, graded in 8 price ranges, from the entry-level explosives starting with 1, to the heritage collections starting with 9, in this mountain, river, lake and sea, your needs are yours!
The numbered grading of LEESON red wine is accurate and meticulous, taking care of all aspects of consumers’ selection according to their needs. Just look at the number to know which price level of LEESON red wine it belongs to. It is very simple and even helps consumers for any purpose. Think clearly!
For example, the ones starting with 1 and 2 are the entry-level red wine series, imported from the original factory, and authorized to repackage. In addition to meeting the drinking needs of entry-level red wine, it can also be used as promotional gifts for supermarkets and corporate welfare distribution. The value series starting with 3 are imported from the original factory with the original bottle, and the price is first-class. In addition to being suitable as daily "ration wine", it can also be used as wine for banquets and for distribution and sale in wine stores. The ones starting with 4 are the quality series, which are imported in original bottles and praised by sommeliers. They are the first choice for wines used in restaurants, bars and salons, and are also good companions for luxury tie-in sales. The treasure series starting with 5 is currently the wine with the highest repurchase rate, a good news for red wine lovers, and a must-have wine for friends' gatherings.
LEESON red wine starts from 6 and above, to the most refined and perfect, gradually becoming top-notch!
The wines starting with 6 are collection series, French AOP, Chilean reserve grade, or the same grade wines. Gift giving is decent, and it is a more down-to-earth wine among the top-tier wines. The premium series starting with 7, oak barrels older than 6 months, family collection, AOP+, is a must-have in the home wine cellar and a favorite of senior wine drinkers. The luxury series starting with 8, from rare production areas, has won awards, and is a hallmark of professional sommeliers. The heritage series starting with 9 comes from well-known wineries, the award-worthy, rare and supreme models, although expensive but super value.
No one can resist this charming red wine! Especially in this area of mountains, rivers, lakes and seas, LEESON red wine numbering and grading method has been fully considered for you, so why do you have any hesitation? All you need to think about now is, which one should you choose!
Yuncang Winery belongs to Hainan Yuncang Winery Co., Ltd., which is an online sales platform for traditional wine business, and is a member unit of China Wine Association.
Yuncang Winery is a combination of Yuncang + Winery. It takes part of the traditional wine business online, supports offline business, and can also purchase online. How to buy offline can be purchased online. Who is the supplier offline? Whoever is the supplier on the commercial line provides Internet online services according to the traditional wine wholesale business. The goods can be picked up in batches or shipped one by one according to the order. Distributors do not advocate stockpiling except for wine for display, and the operation is flexible.

I very much enjoyed going to the video store as a kid. The ritual of picking out a tape or a game was a hallmark of my weekends. I enjoyed watching the cartoons after school or later in the evening on the USA Network or Nickelodeon. Prime time faves such as The A-Team, Knight Rider, Dukes of Hazzard, ALF, or MacGyver we looked forward too.
Today I have a media server with all sorts of complete series available at my fingertips. I have an emulation system with all of the NES, SNES, Atari 2600, and other systems games. I can watch T A-Team or Cheers whenever I want, even on a sick day (sorry Bob Barker). I can play Contra or NBA Jam whenever I wish. If I could get in the Delorean and go be to see my 10 year old self to tell him what he is going to have one day, it would blow his mind!
What is your 10 year old self grateful having today?